1. Introduction
A male has been experiencing a range of health issues that have progressively impacted his quality of life over the past seven months. His primary complaints include neurological symptoms such as slurred speech, tremors, uncoordinated movements, and excessive salivation, likely due to neuromuscular dysfunction. Additionally, he suffers from gastrointestinal issues, including constipation and indigestion, along with disturbed sleep patterns.
2. Patient Information
A 65-year-old male, presented with a 7-month history of a neuromuscular disorder characterized by slurred speech, tremors, uncoordinated movements, disturbed sleep, constipation, indigestion, and increased salivation. Despite initial pharmacological management, his symptoms persisted, prompting the addition of naturopathic interventions. The integrative approach, combining conventional medicine and naturopathy, led to significant improvements in his metabolic and inflammatory markers. This case highlights the effectiveness of a multidisciplinary treatment plan for managing complex neurological and systemic issues.
3. Medication History:
| S.No | Medication | After Treatment | Mechanism |
| 1 | Levodopa100mg-Carbidopa25mg (1-1-1-1) | 1-1-0 | Levodopa is converted into dopamine in the brain to help control motor symptoms, while carbidopa prevents the breakdown of levodopa before it reaches the brain. |
| 2 | Trihexyphenidyl 2mg(1-0-1) | 1-0-1 | Trihexyphenidyl is an anticholinergic drug that works by blocking the action of acetylcholine in the brain. |
| 3 | Multivitamins (1-0-0) | 1-0-0 | Supplementation to address potential nutritional deficiencies, supporting overall health. |
| 4 | Vitamin D (1-0-0) | Tapered | Vitamin D is crucial for bone health, immune function, and helps in the absorption of calcium. |
| 5 | Herbal Supplements (Ashwagandha, Turmeric) | Continued | Ashwagandha is an adaptogen that helps reduce stress and improves neuromuscular function, while turmeric has anti-inflammatory properties that support neuromuscular health. |
The prescribed treatment includes Levodopa100mg-Carbidopa25mg (1-1-1-0), where Levodopa is converted into dopamine in the brain to control motor symptoms, while Carbidopa prevents the breakdown of Levodopa before it reaches the brain. Trihexyphenidyl 2mg(1-0-1) is an anticholinergic drug that blocks the action of acetylcholine in the brain. Multivitamins are continued to address nutritional deficiencies and support overall health. Vitamin D is tapered as it plays a crucial role in bone health, immune function, and calcium absorption. Herbal supplements like Ashwagandha and Turmeric are also continued, with Ashwagandha acting as an adaptogen to reduce stress and improve neuromuscular function, while Turmeric supports neuromuscular health through its anti-inflammatory properties. Fiber supplements are continued to promote bowel regularity and alleviate constipation.
4. Naturopathic and Lifestyle Interventions
His treatment plan included the following naturopathic and lifestyle interventions:
Yoga and Physiotherapy: Tailored sessions aim to improve neuromuscular coordination, enhance flexibility, and alleviate discomfort caused by his symptoms.
Dietary Adjustments: A whole-food, anti-inflammatory diet focuses on improving metabolic health, reducing digestive discomfort, and supporting overall vitality.
Detox Therapies: Specialized treatments help eliminate toxins, promote kidney and liver health, and boost systemic recovery to enhance overall well-being.
Lifestyle Changes: Emphasis on sleep hygiene, stress management, and regular physical activity fosters mental clarity, better cardiovascular health, and improved quality of life.
5. Results and Follow-Up
| S.No | Biomarker | Before Treatment | After Treatment |
| 1 | HbA1c | 7.5% | 6.2% |
| 2 | HOMA-IR | 3.5 | 2.2 |
| 3 | Vitamin D | 15 | 30 |
| 4 | LDL Cholesterol | 160 | 120 |
| 5 | Iron Levels | 42.3 | 73.2 |
| 6 | HS-CRP | 8.0 | 4.2 |
| 7 | Blood Ketone | 0.2 | 2 |
After undergoing treatment, significant improvements were observed in various biomarkers. His HbA1c decreased from 7.5% to 6.2%, reflecting better long-term blood sugar control. The HOMA-IR index, a measure of insulin resistance, improved from 3.5 to 2.2, indicating enhanced insulin sensitivity. Vitamin D levels rose from 15 ng/mL to 30 ng/mL, helping to correct deficiency and support overall health. LDL cholesterol was reduced from 160 mg/dL to 120 mg/dL, lowering the risk of cardiovascular issues. Iron levels improved from 42.3 µg/dL to 73.2 µg/dL, helping to boost energy and reduce fatigue. Finally, HS-CRP, a marker of systemic inflammation, decreased from 8.0 mg/L to 4.2 mg/L, reflecting a reduction in inflammation and improved metabolic balance. Elevated blood ketone levels, rising from 0.2 to 2, indicate enhanced ketone utilization, which supports improved neurological function by providing an efficient energy source for brain metabolism.
6. Discussion
This case underscores the importance of a comprehensive treatment approach that integrates conventional pharmacological therapies with naturopathic interventions. The use of Levodopa-Carbidopa and Trihexyphenidyl helped manage the neuromuscular symptoms, while lifestyle interventions, such as yoga and herbal supplements, targeted underlying systemic issues such as inflammation, digestive health, and sleep disturbances. The improvements in biomarkers further support the efficacy of this integrative approach in managing a complex condition.
7. Conclusion
This case demonstrates the transformative potential of combining pharmacological and naturopathic therapies in managing neuromuscular disorders. His clinical outcomes, including better glycemic control, reduced inflammation, enhanced motor function, and improved sleep, highlight the efficacy of a holistic treatment plan. Continued follow-up and adherence to this integrative approach are expected to sustain these improvements and further enhance his quality of life. Bhanwarlal’s prognosis is positive, with significant improvement in his chief complaints of tremors, uncoordinated movements, disturbed sleep, constipation, and indigestion. His neuromuscular symptoms have improved, and his metabolic and inflammatory markers show a favorable trend. With ongoing adherence to the integrative treatment plan, his quality of life is expected to continue improving.