“Reclaiming life of Mrs. Gandhimathi”
Gandhimathi, a 45-year-old woman, had her life turned upside down when she was diagnosed with Systemic Lupus Erythematosus (SLE) in 2008. Her journey with this chronic illness began with knee pain, which soon spread to other joints, severely impacting her daily activities. Seeking help, she visited Ramachandra Hospital in Chennai, where her diagnosis was confirmed.
Her treatment started with medications such as HCQS, Omnacortil 40mg, multivitamins, folic acid, and vitamin D, which offered some relief from the relentless joint pain. However, the battle was far from over. In 2012, methotrexate (Folitrax) was added to her regimen, helping to manage her symptoms more effectively.
In 2020, seeking further improvement, she transferred her care to SLNS Hospital. The dedicated medical team fine-tuned her treatment plan, and gradually, the joint pain that had plagued her for years began to fade away. Her Omnacortil dosage was tapered, marking a significant milestone in her journey.
In June 2024, Mrs. Gandhimathi returned to Ramachandra Hospital for a reassessment. Her Folitrax medication was tapered over 15 days, a hopeful step towards reducing her dependency on medication. Following this, she revisited SLNS Hospital, where she received the incredible news—she was declared non-SLE. This declaration marked the end of a long, arduous journey and the beginning of a new chapter in her life.
| S.No | Present medication | Medication (After Treatment) | Mechanism of the drug |
| 1 | Hydrochloride sulphate 200mg (0-0-1) | Tapered | Inhibits protein synthesis in susceptible organisms by inhibiting DNA and RNA polymerase. |
| 2 | Folic Acid 5mg(Weekly twice) | Weekly twice | Supplement |
| 3 | Methotrexate 7.5mg(Weekly once) | Tapered | It promotes adenosine release and inhibits transmethylation reactions which reduces inflammation, alleviates pain, and slows disease progression |
MEDICATION TITRATION
Hydroxychloroquine sulfate (200 mg, 0-0-1) inhibits protein synthesis in susceptible organisms, targeting DNA and RNA polymerase. Methotrexate (7.5 mg, weekly once) reduces inflammation, alleviates pain, and slows disease progression by promoting adenosine release and inhibiting transmethylation reactions. Including Folic Acid (5 mg, twice weekly) as a supplement supports overall health, compensating for nutrient depletion caused by Methotrexate. This tailored approach enhances treatment efficacy, patient comfort, and overall outcomes.
| S.No | PARAMETERS | BEFORE TREATMENT | AFTER TREATMENT |
| 1 | ANA | POSITIVE(>1.2) | NEGATIVE (0.41) |
| 2 | Anti ds-DNA Antibody | POSITIVE (>25) | NEGATIVE (19.3) |
| 3 | ANTI-CCP | 7.1 | 5.84 |
| 4 | SGOT | 36.7 | 27.3 |
| 5 | ALKALINE PHOSPHATASE | 156.6 | 127.1 |
| 6 | LEAD | 194.18 | 47.12 |
| 7 | TRIGLYCERIDES | 80 | 97 |
TREATMENT FORECAST
A naturopathy and yoga regimen significantly improved various health biomarkers in just 10 days. ANA levels dropped from positive (>1.2) to negative (0.41), indicating reduced autoimmune activity. Anti ds-DNA Antibody levels decreased from positive (>25) to negative (19.3), reflecting improved DNA integrity. ANTI-CCP levels reduced from 7.1 to 5.84, signaling lower inflammation. SGOT levels dropped from 36.7 to 27.3, and Alkaline Phosphatase from 156.6 to 127.1, both showing enhanced liver function. Lead levels dramatically decreased from 194.18 to 47.12, indicating detoxification. Although Triglycerides increased from 80 to 97, the overall biomarker improvements underscore the health benefits of naturopathy and yoga.