24-Year IT Pro with SLE Sees Health Enhancement
Ms. Supraja ,in February 2014, at the age of 15, she was admitted to Chennai Padmini Nursing Home due to fever. Dr. Pithal prescribed Dolo 650, resulting in a skin reaction turning her skin pink. Despite comprehensive blood tests, the cause remained undetermined. Subsequently, she developed ulcer burns in her mouth up to her throat, impairing her ability to eat. Due to escalating symptoms, she was transferred to Ayisha Hospital in Chennai, where Dr. Bharathwaj administered allopathic medications for fever, providing temporary relief. However, the fever recurred after two days.
In 2014, she sought treatment at JIPMER Hospital in Pondicherry, where comprehensive testing led to a diagnosis of Systemic Lupus Erythematosus (SLE) by Dr. Negi, an immunology specialist. She underwent Intravenous Immunoglobulin (IVIG) therapy for 25 days, resulting in gradual improvement. Additionally, they prescribe prednisolone 40mg HCQ 200mg folate 5mg vitamin d 500mg omeprazole 20mg to manage her condition. However, the medication led to significant weight gain, from 45 to 72 kilograms within two months.
In 2016 august 4, she was again admitted to JIPMER with oral ulcers, polyarthralgia, fever, lymphadenopathy and septicemia they sent blood culture and started on antibiotics-amikacin and ceftriaxone, she was afebrile after 4 days and they added MMF 500mg once a day after 2 years tapered all the medicines and currently she is taking HCQS and Azathioprine.
In July 2023, she experienced abdominal pain and fever, which was diagnosed as 3mm kidney stones. Dr. K. Narayanan, a nephrologist recommended Aldactone syrup, leading to an improvement in her condition.
| S.No | Present medication | Medication (After Treatment) | Mechanism of the drug |
| 1 | Azathioprine 50mg (1-0-0) | Tapered | This inhibition suppresses the proliferation of certain immune cells, particularly T lymphocytes, which are involved in the autoimmune response. |
| 2 | Hydroxychloroquine 300mg (0-0-1) | Tapered | Inhibits antigen processing and presentation and also inhibits inflammatory mediators such as IL -1 ,TNF alpha, prostaglandins. |
| 3 | Prednisolone 40mg (1-0-0) | Tapered | It binds to the glucocorticoid receptor inhibiting proinflammatory signals and promoting anti-inflammatory signals. |
MEDICATION TITRATION
Following naturopathy and yoga integration into her treatment plan, the patient’s medication regimen has been gradually tapered. Azathioprine is now at 50mg once daily, Hydroxychloroquine reduced to 300mg nightly, and Prednisolone tapered to 40mg daily. This approach aims to minimize reliance on pharmaceuticals while enhancing overall well-being through holistic practices.
| S.No | PARAMETERS | Day 1 | Day 20 |
| 1 | HS CRP | 1.3 | 0.6 |
| 2 | HOMA IR | 1.77 | 1.44 |
| 3 | HOMOCYSTEINE | 19.8 | 14.4 |
| 4 | ANA | 178.24 | 119.73 |
| 5 | CORTISOL | 0.06 | 7.2 |
| 6 | TESTOSTERONE | 13.05 | 22.45 |
| 7 | LIPOPROTEIN A | 47.7 | 30.1 |
| 8 | LYMPHOCYTE % | 15.8 | 27.9 |
| 9 | DEOXY CORTISOL | 91.7 | 105.78 |
| 10 | VITAMIN D | 4.51 | 98.39 |
| 11 | VITAMIN B12 | 177 | 231 |
TREATMENT FORECAST
Supraja exhibited significant improvement across various health markers over a 20-day period, suggesting a positive prognosis and enhanced biomarker benefits. HS CRP levels decreased from 1.3 to 0.6, indicating reduced inflammation. Insulin resistance, as measured by HOMA IR, improved from 1.77 to 1.44. Homocysteine levels dropped from 19.8 to 14.4, which is favorable for cardiovascular health.ANA levels decreased from 178.24 to 119.73, reflecting potential autoimmune stabilization. Cortisol levels rise from 0.06 to 7.2, suggesting better adrenal function. Testosterone levels increased from 13.05 to 22.45, indicating improved hormonal balance. Lipoprotein A levels reduced from 47.7 to 30.1, beneficial for heart health. Lymphocyte percentage rise from 15.8 to 27.9, suggesting enhanced immune function. Deoxy cortisol levels increased from 91.7 to 105.78. Vitamin D and B12 levels showed significant improvement, rising from 4.51 to 98.39 and 177 to 231, respectively, indicating better overall nutritional status.